UniProt Q00961

Glutamate receptor ionotropic, NMDA 2C (Q00961)

Glutamate receptor ionotropic, NMDA 2C (UniProt Q00961): 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q00961
Protein: Glutamate receptor ionotropic, NMDA 2C
Experimental structures: 4
Predicted models: 1
Ligands: 4
Pockets: 59 · 4 records with a druggable one

Structures

5 records of Q00961 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7YFG	Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (major class…	electron microscopy	B, D	NAG, GLU	18 (best 0.84)
7YFH	Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine, glutamate and (R)-PYD-106	electron microscopy	B, D	MAN, NAG, IWB	—
7YFI	Structure of the Rat tri-heteromeric GluN1-GluN2A-GluN2C NMDA receptor in complex with glycine and…	electron microscopy	D	NAG, GLU	11 (best 0.85)
8HDK	Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (minor class…	electron microscopy	B, D	NAG	15 (best 0.84)
Q00961	AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2C (Q00961)	predicted	A	—	15 (best 0.74)

Ligands

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
GLU · Glutamic acid · in 2 records
IWB · methyl 4-[(2~{R})-3-ethanoyl-1-[2-(2-methyl-1~{H}-indol-3-yl)ethyl]-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-2-yl]benzoate · in 1 record
MAN · alpha-D-mannopyranose · in 1 record

Experiment against prediction

7YFG chain D against the predicted model Q00961: TM-score 0.84, RMSD 4.10 Å
7YFI chain D against the predicted model Q00961: TM-score 0.84, RMSD 4.09 Å
8HDK chain D against the predicted model Q00961: TM-score 0.84, RMSD 4.10 Å
8HDK chain B against the predicted model Q00961: TM-score 0.84, RMSD 4.03 Å
7YFH chain D against the predicted model Q00961: TM-score 0.83, RMSD 4.25 Å
7YFG chain B against the predicted model Q00961: TM-score 0.80, RMSD 4.50 Å
7YFH chain B against the predicted model Q00961: TM-score 0.80, RMSD 4.59 Å

Elsewhere

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