MolNFT v1 · #264896 · protein

AlphaFold monomer V2.0 prediction for nicastrin (Q8GUM5)

Q8GUM5: “AlphaFold monomer V2.0 prediction for nicastrin (Q8GUM5)”. 8 pockets (best druggability 0.77). MolNFT v1 #264896 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q8GUM5
Type: protein
Length: 676 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xf946795cBBF0d709882f916b7A64276982c26588
Molecule: Nicastrin
UniProt: Q8GUM5
Pockets: 8 · best druggability 0.77

Structure

1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nicastrin	protein	676	38% helix, 21% strand	Q8GUM5

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.77	0.99	24	empty
2	309	0.63	0.80	34	empty
3	239	0.53	0.76	26	empty
4	95	0.44	0.79	23	empty
5	111	0.44	0.77	19	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8GUM5
Elsewhere: UniProt Q8GUM5 · AlphaFold DB Q8GUM5

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