Research workbench
AlphaFold monomer V2.0 prediction for nicastrin (Q8GUM5)
Analyse AlphaFold monomer V2.0 prediction for nicastrin (Q8GUM5) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q8GUM5
- Type
- protein
- Length
- 676 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf946795cBBF0d709882f916b7A64276982c26588
- Molecule
- Nicastrin
- UniProt
- Q8GUM5
- Pockets
- 8 · best druggability 0.77
Structure
1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicastrin | protein | 676 | 38% helix, 21% strand | Q8GUM5 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.77 | 0.99 | 24 | empty |
| 2 | 309 | 0.63 | 0.80 | 34 | empty |
| 3 | 239 | 0.53 | 0.76 | 26 | empty |
| 4 | 95 | 0.44 | 0.79 | 23 | empty |
| 5 | 111 | 0.44 | 0.77 | 19 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8GUM5
- Elsewhere: UniProt Q8GUM5 · AlphaFold DB Q8GUM5
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