MolNFT v1 · #263626 · protein
AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P25799)
P25799: “AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P25799)”. 3 pockets (best druggability 0.51). MolNFT v1 #263626 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P25799
- Type
- protein
- Length
- 971 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb4D2d9c96b0D792d0b77e7147D724cc1F801ae58
- Molecule
- Nuclear factor nf-kappa-B P105 subunit
- UniProt
- P25799
- Pockets
- 3 · best druggability 0.51
Structure
1 distinct chain · 28% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear factor nf-kappa-B P105 subunit | protein | 971 | 28% helix, 13% strand | P25799 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.51 | 0.78 | 28 | empty |
| 2 | 58 | 0.32 | 0.76 | 10 | empty |
| 3 | 54 | 0.30 | 0.76 | 17 | empty |
Compared structures
- 8TKL · Murine NF-kappaB p50 Rel Homology Region homodimer in complex with a Test 16-mer… · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1LE5 · Crystal structure of a nf-kb heterodimer bound to an ifnb-kb · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1LE5 · Crystal structure of a NF-kB heterodimer bound to an IFNb-kB · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1LEI · The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV… · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1LEI · The kb DNA sequence from the hlv-ltr functions as an allosteric regulator of HIV… · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 8TKM · Murine NF-kappaB p50 Rel Homology Region homodimer in complex with 17-mer kappaB DNA from… · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1LE9 · Crystal structure of a nf-kb heterodimer bound to the IG/HIV-kb siti · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1LE9 · Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1NFK · Structure of the nuclear factor kappa-B (nf-kb) P50 homodimer · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 1NFK · Structure of the nuclear factor kappa-B (nf-kb) P50 homodimer · an experimental structure of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25799
- Elsewhere: UniProt P25799 · AlphaFold DB P25799
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