UniProt P25799
Nuclear factor NF-kappa-B p50 subunit (P25799)
Nuclear factor NF-kappa-B p50 subunit (UniProt P25799): 36 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P25799
- Protein
- Nuclear factor NF-kappa-B p50 subunit
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 12 · 3 records with a druggable one
Structures
37 records of P25799 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BFS | Structure of nf-kb P50 homodimer bound to a kb site | x-ray diffraction | A | — | — |
| 1BFS | Structure of nf-kb P50 homodimer bound to a kb site | x-ray diffraction | A | — | — |
| 1IKN | IKAPPABALPHA/NF-kappab complex | x-ray diffraction | C | — | — |
| 1IKN | IKAPPABALPHA/NF-kappab complex | x-ray diffraction | C | — | — |
| 1LE5 | Crystal structure of a NF-kB heterodimer bound to an IFNb-kB | x-ray diffraction | B, F | — | — |
| 1LE5 | Crystal structure of a nf-kb heterodimer bound to an ifnb-kb | x-ray diffraction | B, F | — | — |
| 1LE9 | Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti | x-ray diffraction | B, F | — | — |
| 1LE9 | Crystal structure of a nf-kb heterodimer bound to the IG/HIV-kb siti | x-ray diffraction | B, F | — | — |
| 1LEI | The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription | x-ray diffraction | B | — | — |
| 1LEI | The kb DNA sequence from the hlv-ltr functions as an allosteric regulator of HIV transcription | x-ray diffraction | B | — | — |
| 1NFK | Structure of the nuclear factor kappa-B (nf-kb) P50 homodimer | x-ray diffraction | A, B | — | — |
| 1NFK | Structure of the nuclear factor kappa-B (nf-kb) P50 homodimer | x-ray diffraction | A, B | — | — |
| 1OOA | CRYSTAL STRUCTURE OF NF-kB(p50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER | x-ray diffraction | A, B | — | — |
| 1OOA | Crystal structure of nf-KB(P50)2 complexed to a high- affinity RNA aptamer | x-ray diffraction | A, B | — | — |
| 1U36 | Crystal structure of WLAC mutant of dimerisation domain of NF-kB p50 transcription factor | x-ray diffraction | A | — | — |
| 1U36 | Crystal structure of wlac mutant of dimerisation domain of nf-kb P50 transcription factor | x-ray diffraction | A | — | — |
| 1U3J | Crystal structure of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor | x-ray diffraction | A | — | — |
| 1U3J | Crystal structure of mlav mutant of dimerisation domain of nf-kb P50 transcription factor | x-ray diffraction | A | — | — |
| 1U3Y | Crystal structure of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor | x-ray diffraction | A | — | — |
| 1U3Y | Crystal structure of ilac mutant of dimerisation domain of nf-kb P50 transcription factor | x-ray diffraction | A | — | — |
| 1U3Z | Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor | x-ray diffraction | A | — | — |
| 1U3Z | Crystal structure of mlac mutant of dimerisation domain of nf-kb P50 transcription factor | x-ray diffraction | A | — | — |
| 1U41 | Crystal structure of YLGV mutant of dimerisation domain of NF-kB p50 transcription factor | x-ray diffraction | A, B, C, D | — | — |
| 1U41 | Crystal structure of ylgv mutant of dimerisation domain of nf-kb P50 transcription factor | x-ray diffraction | A, B, C, D | — | — |
| 1U42 | Crystal structure of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor | x-ray diffraction | A | — | — |
| 1U42 | Crystal structure of mlam mutant of dimerisation domain of nf-kb P50 transcription factor | x-ray diffraction | A | — | — |
| 1VKX | Crystal structure of the nfkb P50/P65 heterodimer complexed to the immunoglobulin kb DNA | x-ray diffraction | B | — | — |
| 1VKX | Crystal structure of the nfkb P50/P65 heterodimer complexed to the immunoglobulin kb DNA | x-ray diffraction | B | — | — |
| 2I9T | Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter | x-ray diffraction | B | — | — |
| 2I9T | Structure of nf-kb P65-P50 heterodimer bound to prdii element of B- interferon promoter | x-ray diffraction | B | — | — |
| 2V2T | X-ray structure of a NF-kB p50-RelB-DNA complex | x-ray diffraction | B | — | — |
| 2V2T | X-ray structure of a nf-kb P50-relb-DNA complex | x-ray diffraction | B | — | — |
| 3JV4 | Crystal structure of the dimerization domains p50 and RelB | x-ray diffraction | B, D, F | — | — |
| 3JV4 | Crystal structure of the dimerization domains P50 and relb | x-ray diffraction | B, D, F | — | — |
| 8TKM | Murine NF-kappaB p50 Rel Homology Region homodimer in complex with 17-mer kappaB DNA from human… | x-ray diffraction | A, B | — | 4 (best 0.81) |
| 9BOR | IkappaBzeta ankyrin repeat domain:NF-kappaB p50 homodimer complex at 2.0 Angstrom resolution | x-ray diffraction | B, C | HT3 | 5 (best 0.75) |
| P25799 | AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P25799) | predicted | A | — | 3 (best 0.51) |
Ligands
- HT3 · (2R,3S)-heptane-1,2,3-triol · in 1 record
Experiment against prediction
- 1U36 chain A against the predicted model P25799: TM-score 1.00, RMSD 0.23 Å
- 1U36 chain A against the predicted model P25799: TM-score 1.00, RMSD 0.23 Å
- 1U3Y chain A against the predicted model P25799: TM-score 1.00, RMSD 0.24 Å
- 1U3Y chain A against the predicted model P25799: TM-score 1.00, RMSD 0.24 Å
- 1U3Z chain A against the predicted model P25799: TM-score 1.00, RMSD 0.26 Å
- 1U3Z chain A against the predicted model P25799: TM-score 1.00, RMSD 0.26 Å
- 1U3J chain A against the predicted model P25799: TM-score 1.00, RMSD 0.25 Å
- 1U3J chain A against the predicted model P25799: TM-score 1.00, RMSD 0.25 Å
- 1U41 chain A against the predicted model P25799: TM-score 0.99, RMSD 0.36 Å
- 1U41 chain A against the predicted model P25799: TM-score 0.99, RMSD 0.36 Å
Elsewhere
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