MolNFT v1 · #263009 · protein
AlphaFold monomer V2.0 prediction for negative elongation factor B (Q8WX92)
Q8WX92: “AlphaFold monomer V2.0 prediction for negative elongation factor B (Q8WX92)”. 7 pockets (best druggability 0.66). MolNFT v1 #263009 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8WX92
- Type
- protein
- Length
- 580 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb4D2d9c96b0D792d0b77e7147D724cc1F801ae58
- Molecule
- Negative elongation factor B
- UniProt
- Q8WX92
- Pockets
- 7 · best druggability 0.66
Structure
1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Negative elongation factor B | protein | 580 | 71% helix, 0% strand | Q8WX92 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 376 | 0.66 | 0.80 | 35 | empty |
| 2 | 143 | 0.58 | 0.83 | 24 | empty |
| 3 | 276 | 0.51 | 0.74 | 32 | empty |
| 4 | 93 | 0.42 | 0.78 | 16 | empty |
| 5 | 63 | 0.33 | 0.76 | 15 | empty |
Compared structures
- 8W8E · human co-transcriptional RNA capping enzyme RNGTT · an experimental structure of the same protein · chain A against V, TM-score 0.93
- 8JJ6 · Structure of the NELF-BCE complex · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 8UHD · Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated · an experimental structure of the same protein · chain A against V, TM-score 0.92
- 8UHA · Structure of paused transcription complex Pol II-DSIF-NELF - tilted · an experimental structure of the same protein · chain A against V, TM-score 0.92
- 8UI0 · Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated · an experimental structure of the same protein · chain A against V, TM-score 0.90
- 8UHG · Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated · an experimental structure of the same protein · chain A against V, TM-score 0.90
- 6GML · Structure of paused transcription complex pol II-dsif-nelf · an experimental structure of the same protein · chain A against V, TM-score 0.73
- 7YCX · The structure of INTAC-PEC complex · an experimental structure of the same protein · chain A against f, TM-score 0.73
- 7PKS · Structural basis of Integrator-mediated transcription regulation · an experimental structure of the same protein · chain A against V, TM-score 0.71
- 8RBX · Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome… · an experimental structure of the same protein · chain A against v, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WX92
- Elsewhere: UniProt Q8WX92 · AlphaFold DB Q8WX92
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