UniProt Q8WX92
Negative elongation factor B (Q8WX92)
Negative elongation factor B (UniProt Q8WX92): 9 experimental structures and 1 predicted model on GenesisL1, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WX92
- Protein
- Negative elongation factor B
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 28 · 5 records with a druggable one
Structures
10 records of Q8WX92 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | V | — | — |
| 7PKS | Structural basis of Integrator-mediated transcription regulation | electron microscopy | V | — | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | f | — | — |
| 8JJ6 | Structure of the NELF-BCE complex | x-ray diffraction | A, B | — | 14 (best 0.73) |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | v | — | — |
| 8UHD | Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated | electron microscopy | V | — | — |
| 8UHG | Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated | electron microscopy | V | — | 2 (best 0.77) |
| 8UI0 | Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated | electron microscopy | V | — | 2 (best 0.79) |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | V | — | 3 (best 0.83) |
| Q8WX92 | AlphaFold monomer V2.0 prediction for negative elongation factor B (Q8WX92) | predicted | A | — | 7 (best 0.66) |
Experiment against prediction
- 8W8E chain V against the predicted model Q8WX92: TM-score 0.98, RMSD 1.54 Å
- 8UHD chain V against the predicted model Q8WX92: TM-score 0.96, RMSD 1.70 Å
- 8JJ6 chain A against the predicted model Q8WX92: TM-score 0.96, RMSD 1.81 Å
- 8JJ6 chain B against the predicted model Q8WX92: TM-score 0.96, RMSD 1.83 Å
- 8UI0 chain V against the predicted model Q8WX92: TM-score 0.94, RMSD 2.12 Å
- 8UHG chain V against the predicted model Q8WX92: TM-score 0.94, RMSD 2.12 Å
- 7PKS chain V against the predicted model Q8WX92: TM-score 0.90, RMSD 2.59 Å
- 7YCX chain f against the predicted model Q8WX92: TM-score 0.87, RMSD 3.09 Å
- 6GML chain V against the predicted model Q8WX92: TM-score 0.86, RMSD 3.20 Å
- 8RBX chain v against the predicted model Q8WX92: TM-score 0.80, RMSD 4.10 Å
Elsewhere
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