MolNFT v1 · #262924 · protein

AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46935)

P46935: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46935)”. 10 pockets (best druggability 0.76). MolNFT v1 #262924 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P46935
Type: protein
Length: 887 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xaa53776A41fB2e67da75A96E8a53746b6874aAB4
Molecule: E3 ubiquitin-protein ligase NEDD4
UniProt: P46935
Pockets: 10 · best druggability 0.76

Structure

1 distinct chain · 26% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase NEDD4	protein	887	26% helix, 18% strand	P46935

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	782	0.76	0.81	73	empty
2	685	0.71	0.78	57	empty
3	466	0.58	0.74	40	empty
4	176	0.48	0.76	25	empty
5	76	0.37	0.77	14	empty

Compared structures

3M7F · Crystal structure of the Nedd4 C2/Grb10 SH2 complex · an experimental structure of the same protein · chain A against B, TM-score 0.14
3M7F · Crystal structure of the NEDD4 C2/GRB10 SH2 complex · an experimental structure of the same protein · chain A against B, TM-score 0.14

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46935
Elsewhere: UniProt P46935 · AlphaFold DB P46935

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