MolNFT v1 · #262655 · protein
AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (P15690)
P15690: “AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (P15690)”. 8 pockets (best druggability 0.69). MolNFT v1 #262655 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P15690
- Type
- protein
- Length
- 727 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9e5E98E011361C5888c92e2CDb7652E02Bd5C7Ed
- Molecule
- NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial
- UniProt
- P15690
- Pockets
- 8 · best druggability 0.69
Structure
1 distinct chain · 31% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial | protein | 727 | 31% helix, 17% strand | P15690 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.69 | 0.98 | 21 | empty |
| 2 | 342 | 0.60 | 0.77 | 40 | empty |
| 3 | 186 | 0.57 | 0.81 | 31 | empty |
| 4 | 177 | 0.47 | 0.75 | 29 | empty |
| 5 | 65 | 0.40 | 0.80 | 15 | empty |
Compared structures
- 7QSO · Bovine complex I in lipid nanodisc, state 3 (slack) · an experimental structure of the same protein · chain A against G, TM-score 0.96
- 7QSO · Bovine complex I in lipid nanodisc, State 3 (Slack) · an experimental structure of the same protein · chain A against G, TM-score 0.96
- 7QSL · Bovine complex I in lipid nanodisc, Active-apo · an experimental structure of the same protein · chain A against G, TM-score 0.96
- 7QSL · Bovine complex I in lipid nanodisc, active-apo · an experimental structure of the same protein · chain A against G, TM-score 0.96
- 7QSK · Bovine complex I in lipid nanodisc, Active-Q10 · an experimental structure of the same protein · chain A against G, TM-score 0.96
- 7QSK · Bovine complex I in lipid nanodisc, active-Q10 · an experimental structure of the same protein · chain A against G, TM-score 0.96
- 8Q45 · Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 7QSM · Bovine complex I in lipid nanodisc, Deactive-ligand (composite) · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 7QSM · Bovine complex I in lipid nanodisc, deactive-ligand (composite) · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 7QSN · Bovine complex I in lipid nanodisc, deactive-apo · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 7QSN · Bovine complex I in lipid nanodisc, Deactive-apo · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 8Q46 · Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. · an experimental structure of the same protein · chain A against G, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15690
- Elsewhere: UniProt P15690 · AlphaFold DB P15690
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