MolNFT v1 · #262484 · protein
AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Q99LC3)
Q99LC3: “AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10…”. 3 pockets (best druggability 0.63). MolNFT v1 #262484 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q99LC3
- Type
- protein
- Length
- 355 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbff27Dc0a932A6E0d9Fe883AAbD1BF27bB95A69F
- Molecule
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
- UniProt
- Q99LC3
- Pockets
- 3 · best druggability 0.63
Structure
1 distinct chain · 48% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | protein | 355 | 48% helix, 7% strand | Q99LC3 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 514 | 0.63 | 0.76 | 41 | empty |
| 2 | 237 | 0.59 | 0.80 | 37 | empty |
| 3 | 64 | 0.36 | 0.78 | 19 | empty |
Compared structures
- 8RGT · Open Complex I from murine brain · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8RGQ · Open Complex I from murine liver · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8OLT · Mitochondrial complex I from Mus musculus in the active state bound with piericidin A · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8CA3 · Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8OM1 · Mitochondrial complex I from Mus musculus in the active state · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8C2S · Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8CA5 · Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8RGR · Closed Complex I from murine liver · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 8PW6 · C respirasome from murine liver · an experimental structure of the same protein · chain A against O1, TM-score 0.90
- 8PW5 · CS respirasome from murine liver · an experimental structure of the same protein · chain A against O1, TM-score 0.90
- 7B93 · Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at… · an experimental structure of the same protein · chain A against O, TM-score 0.90
- 7B93 · Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at… · an experimental structure of the same protein · chain A against O, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99LC3
- Elsewhere: UniProt Q99LC3 · AlphaFold DB Q99LC3
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