MolNFT v1 · #258723 · protein
AlphaFold monomer V2.0 prediction for nicotinamide phosphoribosyltransferase (Q99KQ4)
Q99KQ4: “AlphaFold monomer V2.0 prediction for nicotinamide phosphoribosyltransferase (Q99KQ4)”. 6 pockets (best druggability 0.61). MolNFT v1 #258723 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q99KQ4
- Type
- protein
- Length
- 491 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
- Molecule
- Nicotinamide phosphoribosyltransferase
- UniProt
- Q99KQ4
- Pockets
- 6 · best druggability 0.61
Structure
1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicotinamide phosphoribosyltransferase | protein | 491 | 41% helix, 18% strand | Q99KQ4 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.61 | 0.77 | 47 | empty |
| 2 | 247 | 0.51 | 0.75 | 29 | empty |
| 3 | 79 | 0.40 | 0.79 | 19 | empty |
| 4 | 91 | 0.39 | 0.76 | 19 | empty |
| 5 | 83 | 0.34 | 0.75 | 14 | empty |
Compared structures
- 2H3B · Crystal structure of mouse nicotinamide PHOSPHORIBOSYLTRANSFERASE/VISFATIN/PRE-B cell… · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 2H3B · Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell… · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 2H3D · Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell… · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 2H3D · Crystal structure of mouse nicotinamide PHOSPHORIBOSYLTRANSFERASE/VISFATIN/PRE-B cell… · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 7Q8T · Crystal structure of nampt bound to ligand TSY535(COMPOUND 9A) · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 2GVL · Crystal Structure of Murine NMPRTase · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 2GVL · Crystal structure of murine nmprtase · an experimental structure of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99KQ4
- Elsewhere: UniProt Q99KQ4 · AlphaFold DB Q99KQ4
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