AlphaFold monomer V2.0 prediction for 3-hydroxy-3-methylglutaryl- coenzyme a reductase (P13702)

Structure

1 distinct chain · 50% helix, 19% strand (DSSP).

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 1QAX · Ternary complex of pseudomonas mevalonii hmg-CoA reductase with hmg- CoA and NAD+ · an experimental structure of the same protein · chain A against A, TM-score 0.96
• 8GDN · Structure of PmHMGR bound to mevalonate, CoA and NAD. · an experimental structure of the same protein · chain A against A, TM-score 0.95
• 8VLQ · Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation… · an experimental structure of the same protein · chain A against A, TM-score 0.95
• 4I4B · HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate… · an experimental structure of the same protein · chain A against A, TM-score 0.94
• 4I4B · Hmg-CoA reductase from pseudomonas mevalonii complexed with NAD and intermediate… · an experimental structure of the same protein · chain A against A, TM-score 0.94
• 1QAY · Ternary complex of pseudomonas mevalonii hmg-CoA reductase with mevalonate and NAD+ · an experimental structure of the same protein · chain A against A, TM-score 0.89
• 1QAY · Ternary complex of pseudomonas mevalonii hmg-CoA reductase with mevalonate and NAD+ · an experimental structure of the same protein · chain A against A, TM-score 0.89
• 8SZ6 · PmHMGR bound to mevaldehyde and CoA · an experimental structure of the same protein · chain A against A, TM-score 0.88
• 4I6A · 3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii… · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 4I6A · 3-hydroxy-3-methylglutaryl (hmg) coenzyme a reductase from pseudomonas mevalonii… · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 1R31 · HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 1R31 · Hmg-CoA reductase from pseudomonas mevalonii complexed with hmg-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P13702
• Elsewhere: UniProt P13702 · AlphaFold DB P13702