MolNFT v1 · #253413 · protein
AlphaFold monomer V2.0 prediction for methylmalonyl-CoA mutase large subunit (P11653)
P11653: “AlphaFold monomer V2.0 prediction for methylmalonyl-CoA mutase large subunit (P11653)”. 7 pockets (best druggability 0.89). MolNFT v1 #253413 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P11653
- Type
- protein
- Length
- 728 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6DAA77C4263E74E745cA9c4D8E291e57e8991Cf5
- Molecule
- Methylmalonyl-CoA mutase large subunit
- UniProt
- P11653
- Pockets
- 7 · best druggability 0.89
Structure
1 distinct chain · 51% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methylmalonyl-CoA mutase large subunit | protein | 728 | 51% helix, 10% strand | P11653 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1002 | 0.89 | 0.91 | 115 | empty |
| 2 | 157 | 0.65 | 0.86 | 34 | empty |
| 3 | 74 | 0.62 | 0.91 | 22 | empty |
| 4 | 255 | 0.55 | 0.77 | 34 | empty |
| 5 | 122 | 0.43 | 0.76 | 29 | empty |
Compared structures
- 6REQ · Methylmalonyl-CoA mutase, 3-carboxypropyl-CoA inhibitor complex · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 1E1C · Methylmalonyl-CoA mutase H244A mutant · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 1E1C · METHYLMALONYL-COA MUTASE H244A Mutant · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 1REQ · Methylmalonyl-CoA mutase · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 1REQ · Methylmalonyl-CoA mutase · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 4REQ · Methylmalonyl-COA Mutase substrate complex · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 4REQ · Methylmalonyl-CoA mutase substrate complex · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 5REQ · Methylmalonyl-CoA mutase, Y89F mutant, substrate complex · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 7REQ · Methylmalonyl-CoA mutase, 2-carboxypropyl-CoA inhibitor complex · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 7REQ · Methylmalonyl-CoA mutase, 2-carboxypropyl-CoA inhibitor complex · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 2REQ · Methylmalonyl-CoA mutase, non-productive CoA complex, in open conformation representing… · an experimental structure of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11653
- Elsewhere: UniProt P11653 · AlphaFold DB P11653
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