UniProt P11653
Protein (methylmalonyl-CoA mutase alpha-subunit) (P11653)
Protein (methylmalonyl-CoA mutase alpha-subunit) (UniProt P11653), EC 5.4.99.2: 15 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 41 pockets. Binding sites, druggability and experiment against…
- UniProt
- P11653
- Protein
- Protein (methylmalonyl-CoA mutase alpha-subunit)
- EC
- 5.4.99.2
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 41 · 3 records with a druggable one
Structures
16 records of P11653 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E1C | METHYLMALONYL-COA MUTASE H244A Mutant | x-ray diffraction | A, C | — | — |
| 1E1C | Methylmalonyl-CoA mutase H244A mutant | x-ray diffraction | A, C | — | — |
| 1REQ | Methylmalonyl-CoA mutase | x-ray diffraction | A, C | — | — |
| 1REQ | Methylmalonyl-CoA mutase | x-ray diffraction | A, C | — | — |
| 2REQ | Methylmalonyl-CoA mutase, non-productive CoA complex, in open conformation representing… | x-ray diffraction | A, C | — | — |
| 2REQ | Methylmalonyl-CoA mutase, non-productive CoA complex, in open conformation representing… | x-ray diffraction | A, C | — | — |
| 3REQ | Methylmalonyl-CoA mutase, substrate-free state (poor quality structure) | x-ray diffraction | A | — | — |
| 3REQ | Methylmalonyl-CoA mutase, substrate-free state (poor quality structure) | x-ray diffraction | A | — | — |
| 4REQ | Methylmalonyl-COA Mutase substrate complex | x-ray diffraction | A, C | — | — |
| 4REQ | Methylmalonyl-CoA mutase substrate complex | x-ray diffraction | A, C | — | — |
| 5REQ | Methylmalonyl-COA MUTASE, Y89F Mutant, substrate complex | x-ray diffraction | A, C | SCD, MCD, B12 | 18 (best 0.90) |
| 5REQ | Methylmalonyl-CoA mutase, Y89F mutant, substrate complex | x-ray diffraction | A, C | SCD, MCD, B12 | — |
| 6REQ | Methylmalonyl-CoA mutase, 3-carboxypropyl-CoA inhibitor complex | x-ray diffraction | A, C | 3CP, B12 | — |
| 7REQ | Methylmalonyl-CoA mutase, 2-carboxypropyl-CoA inhibitor complex | x-ray diffraction | A, C | 2CP, B12 | 16 (best 0.90) |
| 7REQ | Methylmalonyl-CoA mutase, 2-carboxypropyl-CoA inhibitor complex | x-ray diffraction | A, C | 2CP, B12 | — |
| P11653 | AlphaFold monomer V2.0 prediction for methylmalonyl-CoA mutase large subunit (P11653) | predicted | A | — | 7 (best 0.89) |
Ligands
Experiment against prediction
- 6REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.37 Å
- 5REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.38 Å
- 5REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.38 Å
- 5REQ chain C against the predicted model P11653: TM-score 1.00, RMSD 0.38 Å
- 4REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.39 Å
- 4REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.39 Å
- 1E1C chain A against the predicted model P11653: TM-score 1.00, RMSD 0.39 Å
- 1E1C chain A against the predicted model P11653: TM-score 1.00, RMSD 0.39 Å
- 1REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.40 Å
- 1REQ chain A against the predicted model P11653: TM-score 1.00, RMSD 0.40 Å
Elsewhere
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