MolNFT v1 · #243908 · protein
AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase mrck-1 (O01583)
O01583: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase mrck-1 (O01583)”. 15 pockets (best druggability 0.77). MolNFT v1 #243908 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O01583
- Type
- protein
- Length
- 1,592 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb3c0C983Fc44934AC589D7131C08a72544EBB92E
- Molecule
- SERINE/THREONINE-protein kinase mrck-1
- UniProt
- O01583
- Pockets
- 15 · best druggability 0.77
Structure
1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase mrck-1 | protein | 1592 | 39% helix, 19% strand | O01583 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 712 | 0.77 | 0.82 | 66 | empty |
| 2 | 894 | 0.72 | 0.76 | 60 | empty |
| 3 | 361 | 0.69 | 0.82 | 45 | empty |
| 4 | 597 | 0.64 | 0.75 | 51 | empty |
| 5 | 247 | 0.59 | 0.79 | 42 | empty |
Compared structures
- 7Z6E · Structure of the C1-PH-CNH regulatory module of MRCK1 · an experimental structure of the same protein · chain A against C, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O01583
- Elsewhere: UniProt O01583 · AlphaFold DB O01583
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