MolNFT v1 · #241879 · protein

AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 5 (Q9WVS7)

Q9WVS7 · Dual specificity mitogen-activated protein kinase kinase 5: “AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 5 (Q9WVS7)”. 6 pockets (best druggability 0.75). MolNFT v1 #241879 on…

Accession: Q9WVS7
Type: protein
Length: 448 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x3298b100681D3A2372Bba3b2f282750dD71629B9
Molecule: Dual specificity mitogen-activated protein kinase kinase 5
UniProt: Q9WVS7
Pockets: 6 · best druggability 0.75

Structure

1 distinct chain · 39% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dual specificity mitogen-activated protein kinase kinase 5	protein	448	39% helix, 18% strand	Q9WVS7

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	891	0.75	0.79	98	empty
2	167	0.54	0.79	24	empty
3	170	0.48	0.76	26	empty
4	83	0.44	0.80	18	empty
5	73	0.39	0.78	13	empty

Compared structures

1WI0 · Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5… · an experimental structure of the same protein · chain A against A, TM-score 0.22
1WI0 · Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5… · an experimental structure of the same protein · chain A against A, TM-score 0.22

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WVS7
Elsewhere: UniProt Q9WVS7 · AlphaFold DB Q9WVS7

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