MolNFT v1 · #236310 · protein
AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 3 (P27361)
P27361: “AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 3 (P27361)”. 5 pockets (best druggability 0.67). MolNFT v1 #236310 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P27361
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5881B09f2D8e743400698633641fc1cD2Ed2BE6F
- Molecule
- Mitogen-activated protein kinase 3
- UniProt
- P27361
- Pockets
- 5 · best druggability 0.67
Structure
1 distinct chain · 37% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 3 | protein | 379 | 37% helix, 15% strand | P27361 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 332 | 0.67 | 0.81 | 37 | empty |
| 2 | 80 | 0.48 | 0.83 | 19 | empty |
| 3 | 112 | 0.41 | 0.77 | 20 | empty |
| 4 | 59 | 0.33 | 0.77 | 14 | empty |
| 5 | 70 | 0.28 | 0.73 | 23 | empty |
Compared structures
- 4QTB · Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced… · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4QTB · Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced… · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 6GES · Crystal structure of ERK1 covalently bound to SM1-71 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 6GES · Crystal structure of ERK1 covalently bound to SM1-71 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 2ZOQ · Structural dissection of human mitogen-activated kinase ERK1 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 2ZOQ · Structural dissection of human mitogen-activated kinase ERK1 · an experimental structure of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27361
- Elsewhere: UniProt P27361 · AlphaFold DB P27361
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