UniProt P27361
Mitogen-activated protein kinase 3 (P27361)
Mitogen-activated protein kinase 3 (UniProt P27361), EC 2.7.11.24: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P27361
- Protein
- Mitogen-activated protein kinase 3
- EC
- 2.7.11.24
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 11 · 1 record with a druggable one
Structures
7 records of P27361 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ZOQ | Structural dissection of human mitogen-activated kinase ERK1 | x-ray diffraction | A, B | — | — |
| 2ZOQ | Structural dissection of human mitogen-activated kinase ERK1 | x-ray diffraction | A, B | — | — |
| 4QTB | Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket | x-ray diffraction | A, B | — | — |
| 4QTB | Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket | x-ray diffraction | A, B | — | — |
| 6GES | Crystal structure of ERK1 covalently bound to SM1-71 | x-ray diffraction | A, B | 6H3, EWH, SO4 | 11 (best 0.72) |
| 6GES | Crystal structure of ERK1 covalently bound to SM1-71 | x-ray diffraction | A, B | 6H3, EWH, SO4 | — |
| P27361 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 3 (P27361) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6GES chain A against the predicted model P27361: TM-score 0.99, RMSD 0.92 Å
- 6GES chain A against the predicted model P27361: TM-score 0.99, RMSD 0.92 Å
- 4QTB chain B against the predicted model P27361: TM-score 0.99, RMSD 0.94 Å
- 4QTB chain B against the predicted model P27361: TM-score 0.99, RMSD 0.94 Å
- 4QTB chain A against the predicted model P27361: TM-score 0.99, RMSD 0.99 Å
- 4QTB chain A against the predicted model P27361: TM-score 0.99, RMSD 0.99 Å
- 6GES chain B against the predicted model P27361: TM-score 0.99, RMSD 0.97 Å
- 2ZOQ chain A against the predicted model P27361: TM-score 0.98, RMSD 1.10 Å
- 2ZOQ chain A against the predicted model P27361: TM-score 0.98, RMSD 1.10 Å
Elsewhere
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