Research workbench
Crystal structure of ETV6 bound to a specific DNA sequence
Analyse Crystal structure of ETV6 bound to a specific DNA sequence in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MHG
- Type
- protein + DNA
- Length
- 118 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Specific 14 bp DNA; Complementary specific 14 bp DNA; Transcription factor ETV6
- UniProt
- P97360
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Specific 14 bp DNA | dna | 14 | — | — |
| C | Complementary specific 14 bp DNA | dna | 14 | — | — |
| A | Transcription factor ETV6 | protein | 90 | 44% helix, 18% strand | P97360 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.43 | 0.78 | 15 | empty |
| 2 | 81 | 0.30 | 0.73 | 16 | empty |
Interfaces
3 interfaces between chains.
- B–C · 607 Ų buried · 57 hydrogen bonds · nucleic-nucleic
- B–A · 574 Ų buried · 10 hydrogen bonds · protein-nucleic
- C–A · 476 Ų buried · 9 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97360
- Elsewhere: RCSB PDB 4MHG · PDBe 4MHG · UniProt P97360
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