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Crystal structure of apo-annexin (SM)1
Analyse Crystal structure of apo-annexin (SM)1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MDU
- Type
- protein
- Length
- 717 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Annexin
- UniProt
- C4QH88
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Annexin | protein | 357 | 66% helix, 1% strand | C4QH88 |
| B | Annexin | protein | 360 | 67% helix, 1% strand | C4QH88 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1090 | 0.74 | 0.77 | 101 | empty |
| 2 | 244 | 0.58 | 0.79 | 35 | empty |
| 3 | 213 | 0.53 | 0.78 | 30 | empty |
| 4 | 82 | 0.42 | 0.79 | 16 | empty |
| 5 | 88 | 0.40 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1007 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4MDU · Crystal structure of apo-Annexin (Sm)1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4QH88
- Elsewhere: RCSB PDB 4MDU · PDBe 4MDU · UniProt C4QH88
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