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TPR3 of fimv from P. aeruginosa (PAO1)

Analyse TPR3 of fimv from P. aeruginosa (PAO1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4MBQ
Type: protein
Length: 301 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Motility protein fimv
UniProt: Q9HZA6
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 4 distinct chains · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Motility protein fimv	protein	49	88% helix, 0% strand	Q9HZA6
B, E, F	Motility protein fimv	protein	50	86% helix, 0% strand	Q9HZA6
C	Motility protein fimv	protein	51	84% helix, 0% strand	Q9HZA6
D	Motility protein fimv	protein	51	75% helix, 0% strand	Q9HZA6

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	405	0.56	0.74	37	empty
2	50	0.24	0.72	13	empty

Interfaces

9 interfaces between chains.

A–E · 412 Å² buried · 9 hydrogen bonds · protein-protein
D–F · 379 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 378 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 373 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 334 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4MBQ · TPR3 of FimV from P. aeruginosa (PAO1) · the same entry in another collection · chain F against F, TM-score 1.00
Q9HZA6 · AlphaFold monomer V2.0 prediction for motility hub protein fimv (Q9HZA6) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HZA6
Elsewhere: RCSB PDB 4MBQ · PDBe 4MBQ · UniProt Q9HZA6

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