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Crystal structure of anti-ST2L antibody C2244

Analyse Crystal structure of anti-ST2L antibody C2244 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4MAU
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C2244 light chain; C2244 heavy chain
Ligands: SO4
Pockets: 4 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	C2244 light chain	protein	216	6% helix, 53% strand	—
H	C2244 heavy chain	protein	212	7% helix, 51% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains L, H
GOL · Glycerol · additive · 4 copies · chains L, H
FMT · Formic acid · additive · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	657	0.64	0.75	66	GOL
2	71	0.30	0.73	22	empty
3	68	0.28	0.72	17	empty
4	52	0.26	0.73	18	empty

Interfaces

1 interface between chains.

L–H · 1778 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4MAU · Crystal structure of anti-ST2L antibody C2244 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4MAU · PDBe 4MAU

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