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Crystal structure of human double mutant BETA2-microglobulin Q8H-L65T

Analyse Crystal structure of human double mutant BETA2-microglobulin Q8H-L65T in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4M8V
Type: protein
Length: 197 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-2-microglobulin
UniProt: P61769
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-2-microglobulin	protein	100	0% helix, 51% strand	P61769
B	Beta-2-microglobulin	protein	97	0% helix, 51% strand	P61769

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	235	0.48	0.74	34	empty

Interfaces

1 interface between chains.

A–B · 176 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4M8V · Crystal structure of Human double mutant beta2-microglobulin Q8H-L65T · the same entry in another collection · chain A against A, TM-score 1.00
P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61769
Elsewhere: RCSB PDB 4M8V · PDBe 4M8V · UniProt P61769

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