Research workbench

Crystal structure of the active dimer of zebrafish PLEXINC1 cytoplasmic region

Analyse Crystal structure of the active dimer of zebrafish PLEXINC1 cytoplasmic region in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4M8M
Type: protein
Length: 1,147 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GCN4 coiled-coil fused zebrafish PLEXINC1
UniProt: Q5RGW1
Pockets: 16 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 59% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GCN4 coiled-coil fused zebrafish PLEXINC1	protein	573	60% helix, 7% strand	Q5RGW1
B	GCN4 coiled-coil fused zebrafish PLEXINC1	protein	574	59% helix, 7% strand	Q5RGW1

Pockets

16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	660	0.74	0.80	65	empty
2	57	0.71	0.97	17	empty
3	588	0.71	0.79	54	empty
4	404	0.64	0.78	41	empty
5	409	0.63	0.77	44	empty

Interfaces

1 interface between chains.

A–B · 2305 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4M8M · Crystal structure of the active dimer of zebrafish PlexinC1 cytoplasmic region · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5RGW1
Elsewhere: RCSB PDB 4M8M · PDBe 4M8M · UniProt Q5RGW1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.