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Deciphering the design of the tropomyosin molecule

Analyse Deciphering the design of the tropomyosin molecule in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1IC2
Type
protein
Length
312 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Tropomyosin alpha chain, skeletal muscle
UniProt
P04268
Pockets
3 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 95% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, CTropomyosin alpha chain, skeletal muscleprotein7995% helix, 0% strandP04268
B, DTropomyosin alpha chain, skeletal muscleprotein7795% helix, 0% strandP04268

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12100.460.7427empty
21070.360.7415empty
3700.290.7315empty

Interfaces

5 interfaces between chains.

  • C–D · 2036 Ų buried · 9 hydrogen bonds · protein-protein
  • A–B · 2025 Ų buried · 12 hydrogen bonds · protein-protein
  • B–C · 314 Ų buried · 3 hydrogen bonds · protein-protein
  • A–D · 197 Ų buried · 0 hydrogen bonds · protein-protein
  • A–C · 18 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

  • 1IC2 · Deciphering the design of the tropomyosin molecule · the same entry in another collection · chain A against A, TM-score 1.00
  • P04268 · AlphaFold monomer V2.0 prediction for tropomyosin alpha-1 chain (P04268) · a predicted model of the same protein · chain A against A, TM-score 0.94

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