Research workbench
Crystal structure of anti-rabies glycoprotein Fab 523-11
Analyse Crystal structure of anti-rabies glycoprotein Fab 523-11 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4M43
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fragment antigen-binding 523-11 light chain; Fragment antigen-binding 523-11 heavy chain
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Fragment antigen-binding 523-11 light chain | protein | 213 | 6% helix, 52% strand | — |
| H | Fragment antigen-binding 523-11 heavy chain | protein | 219 | 8% helix, 51% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 600 | 0.64 | 0.75 | 61 | empty |
| 2 | 173 | 0.51 | 0.78 | 25 | empty |
| 3 | 90 | 0.38 | 0.76 | 15 | GOL |
| 4 | 52 | 0.26 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1808 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4M43 · Crystal structure of anti-rabies glycoprotein Fab 523-11 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4M43 · PDBe 4M43
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.