Research workbench
Crystal structure of trypanosoma brucei protein arginine methyltransferase 7 complex with adohcy
Analyse Crystal structure of trypanosoma brucei protein arginine methyltransferase 7… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4M37
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 7
- EC
- 2.1.1.-
- UniProt
- Q582G4
- Ligands
- SAH
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 7 (EC 2.1.1.-) | protein | 337 | 30% helix, 28% strand | Q582G4 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 341 | 0.64 | 0.79 | 39 | SAH |
| 2 | 51 | 0.47 | 0.85 | 16 | empty |
Compared structures
- 4M37 · Crystal structure of Trypanosoma brucei protein arginine methyltransferase 7 complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q582G4 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 7 (Q582G4) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q582G4
- Elsewhere: RCSB PDB 4M37 · PDBe 4M37 · UniProt Q582G4
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