A novel domain in the microcephaly protein cpap suggests a role in centriole architecture

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 43% strand (DSSP).

Ligands and binding sites

• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A
• PGE · Triethylene glycol · additive · chains A
• PG4 · Tetraethylene glycol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 550 Ų buried · 5 hydrogen bonds · protein-protein

Compared structures

• 4LZF · A novel domain in the microcephaly protein CPAP suggests a role in centriole architecture · the same entry in another collection · chain A against A, TM-score 1.00
• Q8JGS1 · AlphaFold monomer V2.0 prediction for scl-interrupting locus protein homolog (Q8JGS1) · a predicted model of the same protein · chain B against A, TM-score 0.35

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt E7FCY1
• Every structure of UniProt Q8JGS1
• Elsewhere: RCSB PDB 4LZF · PDBe 4LZF · UniProt E7FCY1 · UniProt Q8JGS1