Esxa : esxb (semet) hetero-dimer from thermomonospora curvata

Structure

x-ray diffraction · 2 distinct chains · 88% helix, 0% strand (DSSP).

Ligands and binding sites

• ACT · Acetate ion · additive · 9 copies · chains B, A
• GOL · Glycerol · additive · 6 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• B–A · 1608 Ų buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

• 4LWS · EsxA : EsxB (SeMet) hetero-dimer from Thermomonospora curvata · the same entry in another collection · chain B against B, TM-score 1.00
• D1A4H1 · AlphaFold monomer V2.0 prediction for esat-6-like protein esxa (D1A4H1) · a predicted model of the same protein · chain B against A, TM-score 0.90
• D1A4H0 · AlphaFold monomer V2.0 prediction for esat-6-like protein (D1A4H0) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt D1A4H1
• Every structure of UniProt D1A4H0
• Elsewhere: RCSB PDB 4LWS · PDBe 4LWS · UniProt D1A4H1 · UniProt D1A4H0