Research workbench
The crystal structure of the P132A, Y133D mutant of pyrococcus furiosus phosphoglucose isomerase in complex with manganese.
Analyse The crystal structure of the P132A, Y133D mutant of pyrococcus furiosus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LUL
- Type
- protein
- Length
- 378 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate isomerase
- EC
- 5.3.1.9
- UniProt
- P83194
- Ligands
- MN
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 189 | 11% helix, 44% strand | P83194 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.68 | 0.86 | 27 | empty |
| 2 | 161 | 0.65 | 0.86 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1978 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 4LUL · The crystal structure of the P132A, Y133D mutant of Pyrococcus furiosus phosphoglucose… · the same entry in another collection · chain A against A, TM-score 1.00
- P83194 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (P83194) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P83194
- Elsewhere: RCSB PDB 4LUL · PDBe 4LUL · UniProt P83194
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