Research workbench
Structure of mycobacterial nrna homolog reveals multifunctional nuclease activities
Analyse Structure of mycobacterial nrna homolog reveals multifunctional nuclease… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LS9
- Type
- protein
- Length
- 638 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dhh family protein
- UniProt
- A0QVM9
- Ligands
- MN
- Pockets
- 1 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Dhh family protein | protein | 319 | 42% helix, 20% strand | A0QVM9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1076 | 0.79 | 0.81 | 95 | empty |
Interfaces
1 interface between chains.
- A–B · 2053 Ų buried · 38 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 4LS9 · Structure of mycobacterial nrnA homolog reveals multifunctional nuclease activities · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0QVM9
- Elsewhere: RCSB PDB 4LS9 · PDBe 4LS9 · UniProt A0QVM9
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