Research workbench
The crystal structures of the brucella protein tcpb and the tlr adaptor protein tirap show structural differences in microbial tir mimicry
Analyse The crystal structures of the brucella protein tcpb and the tlr adaptor protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LQD
- Type
- protein
- Length
- 125 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein
- UniProt
- P58753
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein | protein | 125 | 46% helix, 19% strand | P58753 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.35 | 0.74 | 21 | empty |
Modifications
Observed in the structure: 2 disulfide, 2 modified (disulfide, artifact).
Compared structures
- 4LQD · The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP… · the same entry in another collection · chain A against A, TM-score 1.00
- P58753 · AlphaFold monomer V2.0 prediction for TOLL/INTERLEUKIN-1 receptor domain-containing… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P58753
- Elsewhere: RCSB PDB 4LQD · PDBe 4LQD · UniProt P58753
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