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Crystal structure of human norovirus RNA-dependent RNA-polymerase in complex with NAF2

Analyse Crystal structure of human norovirus RNA-dependent RNA-polymerase in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4LQ9
Type: protein
Length: 501 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA-polymerase
UniProt: Q2N379
Ligands: 21D, MG
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA-polymerase	protein	501	42% helix, 17% strand	Q2N379

Ligands and binding sites

21D · naphthalene-1,5-disulfonic acid · ligand · 2 copies · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	729	0.71	0.78	68	21D
2	288	0.58	0.77	41	empty
3	73	0.36	0.77	18	empty
4	62	0.33	0.77	15	empty

Compared structures

4LQ9 · Crystal structure of human norovirus RNA-dependent RNA-polymerase in complex with NAF2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2N379
Elsewhere: RCSB PDB 4LQ9 · PDBe 4LQ9 · UniProt Q2N379

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