Research workbench
HA70(D3)-HA17-HA33
Analyse HA70(D3)-HA17-HA33 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LO7
- Type
- protein
- Length
- 1,879 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ha-70; Ha-33; Ha-17
- UniProt
- Q8KHU9, Q45871, Q45878
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ha-70 | protein | 228 | 2% helix, 54% strand | Q8KHU9 |
| B, D, F, H | Ha-33 | protein | 286 | 10% helix, 48% strand | Q45871 |
| C, G | Ha-17 | protein | 139 | 6% helix, 53% strand | Q45878 |
| E | Ha-70 | protein | 229 | 2% helix, 55% strand | Q8KHU9 |
Pockets
20 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1074 | 0.75 | 0.77 | 118 | empty |
| 2 | 238 | 0.54 | 0.77 | 33 | empty |
| 3 | 232 | 0.53 | 0.77 | 28 | empty |
| 4 | 277 | 0.49 | 0.74 | 35 | empty |
| 5 | 174 | 0.45 | 0.75 | 28 | empty |
Interfaces
11 interfaces between chains.
- B–D · 987 Ų buried · 14 hydrogen bonds · protein-protein
- F–H · 966 Ų buried · 13 hydrogen bonds · protein-protein
- B–F · 884 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 784 Ų buried · 8 hydrogen bonds · protein-protein
- E–G · 774 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4LO7 · HA70(D3)-HA17-HA33 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8KHU9
- Every structure of UniProt Q45871
- Every structure of UniProt Q45878
- Elsewhere: RCSB PDB 4LO7 · PDBe 4LO7 · UniProt Q8KHU9 · UniProt Q45871 · UniProt Q45878
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