Research workbench
Crystal structure of the VGLL4-TEAD4 complex
Analyse Crystal structure of the VGLL4-TEAD4 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LN0
- Type
- protein
- Length
- 457 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-3; Transcription cofactor vestigial-like protein 4
- UniProt
- Q62296, Q80V24
- Pockets
- 2 · best druggability 0.85
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-3 | protein | 213 | 17% helix, 47% strand | Q62296 |
| B | Transcriptional enhancer factor tef-3 | protein | 194 | 18% helix, 51% strand | Q62296 |
| C | Transcription cofactor vestigial-like protein 4 | protein | 50 | 60% helix, 8% strand | Q80V24 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A, B, C
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1165 | 0.85 | 0.85 | 124 | PEG |
| 2 | 104 | 0.39 | 0.76 | 21 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1088 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 576 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 33 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4LN0 · Crystal structure of the VGLL4-TEAD4 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q62296 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q62296) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q80V24 · AlphaFold monomer V2.0 prediction for transcription cofactor vestigial-like protein 4… · a predicted model of the same protein · chain C against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62296
- Every structure of UniProt Q80V24
- Elsewhere: RCSB PDB 4LN0 · PDBe 4LN0 · UniProt Q62296 · UniProt Q80V24
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