Research workbench
Triazine hydrolase from arthobacter aurescens modified for maximum expression in E.COLI
Analyse Triazine hydrolase from arthobacter aurescens modified for maximum expression… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LH8
- Type
- protein
- Length
- 911 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Triazine hydrolase
- EC
- 3.8.1.8
- UniProt
- Q6SJY7
- Ligands
- ZN
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Triazine hydrolase (EC 3.8.1.8) | protein | 456 | 39% helix, 23% strand | Q6SJY7 |
| B | Triazine hydrolase (EC 3.8.1.8) | protein | 455 | 38% helix, 23% strand | Q6SJY7 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.80 | 0.98 | 35 | empty |
| 2 | 119 | 0.78 | 0.97 | 27 | empty |
| 3 | 253 | 0.74 | 0.88 | 40 | empty |
| 4 | 207 | 0.58 | 0.80 | 25 | empty |
| 5 | 198 | 0.53 | 0.78 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 2730 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
- 4LH8 · Triazine hydrolase from Arthobacter aurescens modified for maximum expression in E.coli · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6SJY7
- Elsewhere: RCSB PDB 4LH8 · PDBe 4LH8 · UniProt Q6SJY7
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