Research workbench
Native crystal structure of the recombinant monoclonal wild type anti-testosterone Fab fragment
Analyse Native crystal structure of the recombinant monoclonal wild type… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1I9I
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recombinant monoclonal anti-testosterone Fab fragment light chain; Recombinant monoclonal…
- UniProt
- Q99M37, Q9R1A4
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Recombinant monoclonal anti-testosterone Fab fragment light chain | protein | 219 | 5% helix, 51% strand | Q99M37 |
| H | Recombinant monoclonal anti-testosterone Fab fragment heavy chain | protein | 220 | 5% helix, 49% strand | Q9R1A4 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 571 | 0.63 | 0.75 | 60 | empty |
| 2 | 375 | 0.61 | 0.77 | 46 | empty |
| 3 | 75 | 0.30 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- L–H · 1953 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1I9I · Native crystal structure of the recombinant monoclonal wild type anti-testosterone Fab… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99M37
- Every structure of UniProt Q9R1A4
- Elsewhere: RCSB PDB 1I9I · PDBe 1I9I · UniProt Q99M37 · UniProt Q9R1A4
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