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Structure of the ALS3 adhesin from candida albicans, residues 1-299 (mature sequence) in complex with hepta-threonine
Analyse Structure of the ALS3 adhesin from candida albicans, residues 1-299 (mature… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LEB
- Type
- protein
- Length
- 306 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Agglutinin-like protein 3; Hepta-threonine
- UniProt
- O74623
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Agglutinin-like protein 3 | protein | 299 | 3% helix, 57% strand | O74623 |
| B | Hepta-threonine | protein | 7 | 0% helix, 29% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.59 | 0.82 | 23 | empty |
| 2 | 87 | 0.33 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 518 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4LEB · Structure of the Als3 adhesin from Candida albicans, residues 1-299 (mature sequence) in… · the same entry in another collection · chain A against A, TM-score 1.00
- O74623 · AlphaFold monomer V2.0 prediction for agglutinin-like protein 3 (O74623) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74623
- Elsewhere: RCSB PDB 4LEB · PDBe 4LEB · UniProt O74623
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