Research workbench
Crystal structure of a chey-like protein (tadz) from pseudomonas aeruginosa PAO1 at 2.70 a resolution
Analyse Crystal structure of a chey-like protein (tadz) from pseudomonas aeruginosa… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LDA
- Type
- protein
- Length
- 990 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tadz
- UniProt
- Q9HW97
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 6 distinct chains · 46% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, H | Tadz | protein | 127 | 45% helix, 19% strand | Q9HW97 |
| B, C | Tadz | protein | 128 | 45% helix, 19% strand | Q9HW97 |
| D | Tadz | protein | 120 | 48% helix, 23% strand | Q9HW97 |
| E | Tadz | protein | 120 | 47% helix, 23% strand | Q9HW97 |
| F | Tadz | protein | 121 | 46% helix, 21% strand | Q9HW97 |
| G | Tadz | protein | 119 | 47% helix, 24% strand | Q9HW97 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 14 copies · chains A, B, G, C, D, E, F, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1053 | 0.82 | 0.84 | 108 | empty |
| 2 | 708 | 0.77 | 0.82 | 75 | empty |
| 3 | 186 | 0.44 | 0.74 | 35 | SO4 |
| 4 | 61 | 0.30 | 0.74 | 11 | empty |
Interfaces
13 interfaces between chains.
- G–H · 741 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 716 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 651 Ų buried · 1 hydrogen bond · protein-protein
- F–H · 606 Ų buried · 7 hydrogen bonds · protein-protein
- C–E · 596 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 4LDA · Crystal structure of a CheY-like protein (tadZ) from Pseudomonas aeruginosa PAO1 at 2.70… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HW97
- Elsewhere: RCSB PDB 4LDA · PDBe 4LDA · UniProt Q9HW97
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