Research workbench
Crystal structure and versatile functional roles of the COP9 signalosome subunit 1
Analyse Crystal structure and versatile functional roles of the COP9 signalosome… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LCT
- Type
- protein
- Length
- 1,335 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- COP9 signalosome complex subunit 1
- UniProt
- P45432
- Ligands
- SO4
- Pockets
- 17 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | COP9 signalosome complex subunit 1 | protein | 318 | 76% helix, 0% strand | P45432 |
| B, D | COP9 signalosome complex subunit 1 | protein | 348 | 73% helix, 0% strand | P45432 |
| C | COP9 signalosome complex subunit 1 | protein | 321 | 73% helix, 0% strand | P45432 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 243 | 0.67 | 0.83 | 31 | empty |
| 2 | 278 | 0.66 | 0.82 | 24 | empty |
| 3 | 249 | 0.63 | 0.81 | 24 | empty |
| 4 | 215 | 0.61 | 0.81 | 24 | empty |
| 5 | 146 | 0.47 | 0.77 | 26 | empty |
Interfaces
4 interfaces between chains.
- C–D · 622 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 618 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 584 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 393 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4LCT · Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1 · the same entry in another collection · chain D against D, TM-score 1.00
- P45432 · AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 1 (P45432) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45432
- Elsewhere: RCSB PDB 4LCT · PDBe 4LCT · UniProt P45432
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