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Anti canine CD28 antibody, 1C6

Analyse Anti canine CD28 antibody, 1C6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4LCI
Type: protein
Length: 237 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti canine CD28 antibody, 1C6, light chain; Anti canine CD28 antibody, 1C6, heavy chain
Ligands: NA
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Anti canine CD28 antibody, 1C6, light chain	protein	117	3% helix, 47% strand	—
H	Anti canine CD28 antibody, 1C6, heavy chain	protein	120	10% helix, 48% strand	—

Ligands and binding sites

NA · Sodium ion · metal · chains L
FMT · Formic acid · additive · 4 copies · chains L, H
GOL · Glycerol · additive · 2 copies · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.40	0.76	21	FMT
2	135	0.40	0.74	26	empty

Interfaces

1 interface between chains.

L–H · 693 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4LCI · Anti canine CD28 antibody, 1C6 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4LCI · PDBe 4LCI

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