Research workbench
Crystal structure of a therapeutic single chain antibody in complex with 4-hydroxymethamphetamine
Analyse Crystal structure of a therapeutic single chain antibody in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LAS
- Type
- protein
- Length
- 232 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Single chain antibody fragment SCFV6H4
- Ligands
- 1WF
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Single chain antibody fragment SCFV6H4 | protein | 232 | 8% helix, 49% strand | — |
Ligands and binding sites
- 1WF · 4-[(2S)-2-(methylamino)propyl]phenol · ligand · chains H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.60 | 0.89 | 17 | 1WF |
| 2 | 105 | 0.47 | 0.80 | 19 | empty |
| 3 | 56 | 0.27 | 0.74 | 12 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4LAS · Crystal structure of a therapeutic single chain antibody in complex with… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4LAS · PDBe 4LAS
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