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Crystal structure of apo A12K/D35S mutant myo-inositol dehydrogenase from bacillus subtilis

Analyse Crystal structure of apo A12K/D35S mutant myo-inositol dehydrogenase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4L9R
Type: protein
Length: 337 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inositol 2-DEHYDROGENASE/D-chiro-inositol 3-dehydrogenase
EC: 1.1.1.18
UniProt: P26935
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inositol 2-DEHYDROGENASE/D-chiro-inositol 3-dehydrogenase (EC 1.1.1.18)	protein	337	39% helix, 23% strand	P26935

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	383	0.64	0.79	50	empty
2	106	0.37	0.75	18	empty

Compared structures

4L9R · Crystal Structure of apo A12K/D35S mutant myo-inositol dehydrogenase from Bacillus… · the same entry in another collection · chain A against A, TM-score 1.00
P26935 · AlphaFold monomer V2.0 prediction for inositol 2-DEHYDROGENASE/D-chiro-inositol… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26935
Elsewhere: RCSB PDB 4L9R · PDBe 4L9R · UniProt P26935

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