Research workbench

Complexe of arno SEC7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-DIMETHYLPHENYL)BENZENESULFONAMIDE at PH6.5

Analyse Complexe of arno SEC7 domain with the protein-protein interaction inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4L5M
Type: protein
Length: 196 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytohesin-2
UniProt: Q99418
Ligands: HRC, PO4
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytohesin-2	protein	196	65% helix, 1% strand	Q99418

Ligands and binding sites

HRC · N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide · ligand · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.52	0.79	17	HRC

Compared structures

4L5M · Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
Q99418 · AlphaFold monomer V2.0 prediction for cytohesin-2 (Q99418) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99418
Elsewhere: RCSB PDB 4L5M · PDBe 4L5M · UniProt Q99418

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.