Research workbench
Structure of ESPG3 chaperone from the type VII (esx-3) secretion system
Analyse Structure of ESPG3 chaperone from the type VII (esx-3) secretion system in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4L4W
- Type
- protein
- Length
- 529 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ESPG3
- UniProt
- A0QQ45
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ESPG3 | protein | 262 | 36% helix, 31% strand | A0QQ45 |
| B | ESPG3 | protein | 267 | 35% helix, 30% strand | A0QQ45 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.76 | 0.83 | 76 | empty |
| 2 | 258 | 0.63 | 0.81 | 29 | empty |
| 3 | 257 | 0.61 | 0.80 | 26 | empty |
| 4 | 83 | 0.37 | 0.76 | 21 | empty |
| 5 | 61 | 0.30 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 999 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 4L4W · Structure of EspG3 chaperone from the type VII (ESX-3) secretion system · the same entry in another collection · chain A against A, TM-score 1.00
- A0QQ45 · AlphaFold monomer V2.0 prediction for esx-3 secretion-associated protein ESPG3 (A0QQ45) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0QQ45
- Elsewhere: RCSB PDB 4L4W · PDBe 4L4W · UniProt A0QQ45
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