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Chalcone synthase (G256F)

Analyse Chalcone synthase (G256F) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I8B
Type: protein
Length: 776 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chalcone synthase 2
EC: 2.3.1.74
UniProt: P30074
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Chalcone synthase 2 (EC 2.3.1.74)	protein	388	43% helix, 23% strand	P30074

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	200	0.60	0.81	31	empty
2	233	0.59	0.79	29	empty
3	236	0.46	0.73	27	empty

Interfaces

1 interface between chains.

A–B · 32 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

1I8B · Chalcone synthase (G256F) · the same entry in another collection · chain A against A, TM-score 1.00
P30074 · AlphaFold monomer V2.0 prediction for chalcone synthase 2 (P30074) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30074
Elsewhere: RCSB PDB 1I8B · PDBe 1I8B · UniProt P30074

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