Research workbench

Chalcone synthase (G256L)

Analyse Chalcone synthase (G256L) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I89
Type: protein
Length: 776 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chalcone synthase 2
EC: 2.3.1.74
UniProt: P30074
Pockets: 5 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Chalcone synthase 2 (EC 2.3.1.74)	protein	388	43% helix, 21% strand	P30074

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.72	0.96	28	empty
2	94	0.67	0.92	34	empty
3	250	0.62	0.80	30	empty
4	206	0.60	0.81	30	empty
5	175	0.41	0.72	22	empty

Interfaces

1 interface between chains.

A–B · 33 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

1I89 · Chalcone synthase (G256L) · the same entry in another collection · chain A against A, TM-score 1.00
P30074 · AlphaFold monomer V2.0 prediction for chalcone synthase 2 (P30074) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30074
Elsewhere: RCSB PDB 1I89 · PDBe 1I89 · UniProt P30074

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