Research workbench
Chalcone synthase (G256V)
Analyse Chalcone synthase (G256V) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1I88
- Type
- protein
- Length
- 778 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chalcone synthase 2
- EC
- 2.3.1.74
- UniProt
- P30074
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chalcone synthase 2 (EC 2.3.1.74) | protein | 389 | 44% helix, 23% strand | P30074 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.66 | 0.89 | 24 | empty |
| 2 | 97 | 0.63 | 0.89 | 24 | empty |
| 3 | 233 | 0.62 | 0.81 | 30 | empty |
| 4 | 267 | 0.61 | 0.79 | 31 | empty |
| 5 | 145 | 0.38 | 0.72 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 25 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30074
- Elsewhere: RCSB PDB 1I88 · PDBe 1I88 · UniProt P30074
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