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Crystal structure of the V658F apo JAK1 pseudokinase domain

Analyse Crystal structure of the V658F apo JAK1 pseudokinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4L01
Type: protein
Length: 548 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase JAK1
EC: 2.7.10.2
UniProt: P23458
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase JAK1 (EC 2.7.10.2)	protein	274	45% helix, 18% strand	P23458
B	Tyrosine-protein kinase JAK1 (EC 2.7.10.2)	protein	274	47% helix, 18% strand	P23458

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	330	0.81	0.91	31	empty
2	332	0.65	0.80	54	empty
3	282	0.65	0.81	48	empty
4	163	0.54	0.80	20	empty
5	86	0.52	0.83	12	empty

Interfaces

1 interface between chains.

A–B · 1379 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

4L01 · Crystal structure of the V658F apo Jak1 pseudokinase domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23458
Elsewhere: RCSB PDB 4L01 · PDBe 4L01 · UniProt P23458

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