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Structure of human ARGONAUTE1 in complex with guide RNA

Analyse Structure of human ARGONAUTE1 in complex with guide RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KXT
Type: protein + RNA
Length: 816 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein argonaute-1; RNA
UniProt: Q9UL18
Pockets: 7 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein argonaute-1	protein	806	33% helix, 27% strand	Q9UL18
B	RNA	rna	10	—	—

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1026	0.80	0.82	86	empty
2	211	0.54	0.78	30	empty
3	74	0.42	0.80	21	empty
4	76	0.39	0.79	23	empty
5	56	0.32	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 1680 Å² buried · 49 hydrogen bonds · protein-nucleic

Compared structures

4KXT · Structure of human ARGONAUTE1 in complex with guide RNA · the same entry in another collection · chain A against A, TM-score 1.00
Q9UL18 · AlphaFold monomer V2.0 prediction for protein argonaute-1 (Q9UL18) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UL18
Elsewhere: RCSB PDB 4KXT · PDBe 4KXT · UniProt Q9UL18

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